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Reproductive health research reveals significant applications in studying age-related endocrine dysfunction, with laboratory studies showing that FOXO4-DRI improves the testicular microenvironment and alleviates age-related testosterone secretion insufficiency by targeting senescent Leydig cells in aged male mice

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Nat Rev Clin Oncol 15(5):310324 Georganaki M, van Hooren L, Dimberg A (2018) Vascular targeting to increase the efficiency of immune checkpoint blockade in cancer